Graduate Student Education Education: B.Sc. University of Guelph, 2019 Research Research Interests: Organic Chemistry, Medicinal Chemistry Selected Publications Selected Publications: Hill, J.; Jones, R. M.; Crich, D. Atypical N-Alkyl to N-Noralkoxy Switch in a Dual cSRC/BCR-ABL1 Kinase Inhibitor Improves Drug Efflux and hERG Affinity. ACS Med. Chem. Lett. 2023, 14, 1869-1875. https://doi.org/10.1021/acsmedchemlett.3c00479 Hill, J.; Jones, R. M.; Crich, D. Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer. J. Med. Chem. 2023, 66, 15477-15492. https://doi.org/10.1021/acs.jmedchem.3c01669 Hill, J.; Beckler, T. D.; Crich, D. Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines. Molecules 2023, 28, 2816. https://www.mdpi.com/1420-3049/28/6/2816 Hill, J.; Crich, D. The N,N,O-Trisubstituted Hydroxylamine Isostere and Its Influence on Lipophilicity and Related Parameters. ACS Med. Chem. Lett. 2022, 13, 799-806. https://doi.org/10.1021/acsmedchemlett.1c00713 Freitas, B. T.; Ahiadorme, D. A.; Bagul, R. S.; Durie, I. A.; Ghosh, S.; Hill, J.; Kramer, N. E.; Murray, J.; O'Boyle, B. M.; Onobun, E.; Pirrone, M. G.; Shepard, J. D.; Enos, S.; Subedi, Y. P.; Upadhyaya, K.; Tripp, R. A.; Cummings, B. S.; Crich, D.; Pegan, S. D. Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses. ACS Infect. Dis. 2022, 8, 596-611. https://doi.org/10.1021/acsinfecdis.1c00631 Hill, J.; Crich, D. Synthesis of O-tert-Butyl-N,N-disubstituted Hydroxylamines by N-O Bond Formation. Org. Lett. 2021, 23, 6396-6400. https://doi.org/10.1021/acs.orglett.1c02215 Nasr, P.; Corrandini, M. G.; Hill, J.; Read, S. T.; Rosendahl, S. M.; Weiss, R. G.; Auzanneau, F.-I.; Rogers, M. A. Hansen Solubility Parameters Clarify the Role of the Primary and Secondary Hydroxyl Groups on the Remarkable Self-Assembly of 1:3,2:4-Dibenzylidene Sorbitol. J. Phys. Chem. C 2020, 124, 26455. https://doi.org/10.1021/acs.jpcc.0c07671 Hill, J.; Hettikankanamalage, A. A.; Crich, D. Diversity-Oriented Synthesis of N,N,O-Trisubstituted Hydroxylamines from Alcohols and Amines by N-O Bond Formation. J. Am. Chem. Soc. 2020, 142, 14820. https://doi.org/10.1021/jacs.0c05991 Hill, J.; Wicks, C.; Pounder, A.; Tam, W. Iridium-Catalyzed Ring-Opening Reactions of Unsymmetrical Oxabenzonorbornadienes with Water and Alcohol Nucleophiles. Tetrahedron Lett. 2019, 60, 150990. https://doi.org/10.1016/j.tetlet.2019.150990 Hill, J.; Tam, W. Palladium/Lewis Acid Cocatalyzed Ring-Opening Reactions of Unsymmetrical Oxabenzonorbornadienes with Oximes. J. Org. Chem. 2019, 84, 8309. https://doi.org/10.1021/acs.joc.9b01094 Lough, A. J.; Hill, J.; Tam, W. 1-[(1R*, 2R*)-1,2-Dihydroxy-1,2-dihydronaphthalen-1-yl]ethan-1-one. IUCrData 2019, 4, x190609. https://doi.org/10.1107/S2414314619006096
