Professor and Graduate Coordinator Education Education: Postdoc National Institutes of Health 2009-2011 Postdoc Stanford University 2008-2009 Ph.D. Brown University 2004-2008 B.S. Nanjing University 1999-2003 Research Research Areas: Materials Chemistry and Nanoscience Research Interests: The Xie Lab focuses on pioneering nanoparticle-based approaches for cancer imaging and therapy. Our recent research areas include salt nanoparticle therapeutics, nanoparticle stimulators to enhance immunotherapy, nanoparticle-based radiosensitizers, X-ray induced photodynamic therapy, and cell-based drug delivery. Dr. Xie has received numerous awards, including the NSF CAREER Award, NIH Pathway to Independence Award, DoD Peer Reviewed Cancer Research Program Idea Award, Nano Research Young Innovator Award in Nanobiotechnology, and the NIBIB Outstanding Researcher Award. He also serves as Deputy Editor for the Journal of Nanobiotechnology. Selected Publications Selected Publications: Wei Yang, Zhizi Feng, Xinning Lai, Jianwen Li, Zhengwei Cao, Fangchao Jiang, Fanghui Chen, Shuyue Zhan, Feng Kong, Li Yang, Yong Teng, Wendy Watford, Gang Zhou, Jin Xie. Calcium Nanoparticles Target and Activate T cells to Enhance Anti-tumor Function. Nature Communications, in press. Fanghui Chen, Chris Tang, Fan Yang, Asari Ekpenyong, Richard Qin, Jin Xie, Fatemeh Heravi, Nabil Saba, and Yong Teng. HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck squamous cell carcinoma. Science Advances, 2024, 10, eadk3663. Zhengwei Cao, Xueyuan Yang, Wei Yang, Fanghui Chen, Wen Jiang, Shuyue Zhan, Fangchao Jiang, Jianwen Li, Chenming Ye, Liwei Lang, Sirui Zhang, Zhizi Feng, Xinning Lai, Yang Liu, Leidong Mao, Houjian Cai, Yong Teng, and Jin Xie. Modulation of Dendritic Cell Function via Nanoparticle-Induced Cytosolic Calcium Changes. ACS Nano, 2024, 18(10), 7618-7632. Benjamin L Cline, Wen Jiang, Chaebin Lee, Zhengwei Cao, Xueyuan Yang, Shuyue Zhan, Harrison Chong, Tao Zhang, Zhaoguo Han, Xuedan Wu, Li Yao, Hui Wang, Weizhong Zhang, Zibo Li, Jin Xie. Potassium Iodide Nanoparticles Enhance Radiotherapy against Breast Cancer by Exploiting the Sodium-Iodide Symporter. ACS Nano, 2021,15(11),17401-17411. Rie Kamiyama, Kota Banzai, Peiwei Liu, Abhijit Marar, Ryo Tamura, Fangchao Jiang, Miyuki A. Fitch, Jin Xie, and Daichi Kamiyama. Cell-type–specific, multicolor labeling of endogenous proteins with split fluorescent protein tags in Drosophila. PNAS 2021 118 (23) e2024690118. Jiang W, Yin L, Chen H, Paschall AV, Zhang L, Fu W, Zhang W, Todd T, Yu KS, Zhou S, Zhen Z, Butler M, Yao L, Zhang F, Shen Y, Li Z, Yin A, Yin H, Wang X, Avci FY, Yu X, Xie J. NaCl Nanoparticles as a Cancer Therapeutic. Adv Mater. 2019 Nov;31(46):e1904058. Tang W, Fan W, Zhang W, Yang Z, Li L, Wang Z, Chiang YL, Liu Y, Deng L, He L, Shen Z, Jacobson O, Aronova MA, Jin A, Xie J, Chen X. Wet/Sono-Chemical Synthesis of Enzymatic Two-Dimensional MnO2 Nanosheets for Synergistic Catalysis-Enhanced Phototheranostics. Adv. Mater., 2019, 31(19):e1900401. Weizhong Zhang, Mengzhe Wang, Wei Tang, Ru Wen, Shiyi Zhou, Chaebin Lee, Hui Wang, Wen Jiang, Ian Michael Delahunty, Zipeng Zhen, Hongmin Chen, Matthew Chapman, Zhanhong Wu, Elizabeth W. Howerth, Houjian Cai, Zibo Li, and Jin Xie. Nanoparticle‐Laden Macrophages for Tumor‐Tropic Drug Delivery. Advanced Materials, 2018, 30, 1805557. Tang, W, Fan, W, Wang, Z, Zhang, W, Zhou, S, Liu, Y, Yang, Z, Shao, E, Zhang, G, Jacobson, O, Shan, L, Tian, R, Cheng, S, Lin, L, Dai, Y, Shen, Z, Niu, G, Xie, J, Chen, X. Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy. ACS Nano, 2018, 12(12), 12269–12283. Hongmin Chen, Yuwei Qiu, Dandan Ding, Huirong Lin, Wenjing Sun, Geoffrey D. Wang, Weicheng Huang, Weizhong Zhang, Daye Lee, Gang Liu, Jin Xie, Xiaoyuan Chen. Gadolinium‐Encapsulated Graphene Carbon Nanotheranostics for Imaging‐Guided Photodynamic Therapy. Advanced Materials, 2018, 30, 1802748. Hongmin Chen, Weizhong Zhang, Guizhi Zhu, Jin Xie, and Xiaoyuan Chen. Rethinking Cancer Nanotheranostics. Nature Reviews Materials, 2017, 2, 17024.
