Research in Biological and Carbohydrate Chemistry includes the study of the structures and functions of proteins and complex carbohydrates to determine their roles in growth and development, host-pathogen interactions, and disease processes. To investigate their chemistry and their physiological, developmental, and molecular biology, these research groups develop and use advanced analytical techniques, including mass spectrometry, NMR, EPR, and Raman spectroscopies, chemical and enzymatic synthesis, computer modeling, artificial neural networks, tissue culture, immunocytochemistry, and recombinant genetics.
Personnel
The research projects in our laboratory concern hyperthermophiles, which are microorganisms that grow near and even above 100°C. The main focus is the archaeon Pyrococcus furiosus (Pf), which grows optimally at the boiling point. The Pf genome contains 2,200 genes and a proteomics effort is in progress involving the large-scale fractionation of…
My research group specializes in the development and application of Fourier transform mass spectrometry for solving difficult problems in bioanalytical chemistry. We are exploring new methods for analyzing the structural features of glycosaminoglycans (GAGs), a class of carbohydrates that play a central role in a number of important biological…
Protein- and lipid-bound saccharides play essential roles in many molecular processes impacting eukaryotic biology and disease. Progress in glycoscience is, however, hampered by the inaccessibility of well-defined oligosaccharides and glycoconjugates for biological and biomedical studies. My laboratory is addressing these issues by developing…
To increase our understanding of biology and medicine, the scientific community requires the continued development of new technologies for studying and manipulating cell physiology. The research interests of the Dore Laboratory at NYUAD lie at the interface of chemistry and biology, creating new technology to study complex biological systems.…
The research in the Harrop group focuses on aspects in the area of bioinorganic chemistry. These interests include the rational design and synthesis of structural and functional models of metalloenzyme active sites involved in small molecule activation, especially the superoxide detoxifying enzymes like superoxide reductase (SOR, a non-heme…
Our goal is to better understand the ways in which lipids and small molecules contribute to diseases affecting human health and use this knowledge to develop diagnostic and prognostic tools based on molecular signatures of the disease. To achieve this, the Hines Lab develops and applies bioanalytical methods using ion mobility-mass spectrometry…
Our research concerns the role and assembly of transition metal centers in metalloenzymes and metalloproteins. Metal centers constitute the active sites of at least one third of all enzymes and determining the assembly mechanism of metallocenters and the electronic and structural properties of metal centers that confer selective and specific…
Introduction- In general, a very broad description of the work of interest to this laboratory are the mechanisms of metalloproteins involved in radical generation, oxidative stress protection, as well as heme synthesis, sensing, aquisition and transport.
With very few exceptions, heme is required by most organisms for a vast array of…
Our research focuses on the use of mass spectrometry to answer biological/biomedical questions. The majority of our projects involve characterizing the post-translational modifications (e.g., glycosylation, phosphorylation) present on the protein of interest. For example, we are currently investigating the in vivo changes that occur in human…
Enzymes are remarkable biocatalysts, not only for the dramatic rate accelerations (up to 1020 fold) that they provide, but also for the high degree of substrate specificity, regiospecificity and stereospecificity that these reactions exhibit. The work in my laboratory is focused on the chemical basis for how enzymes achieve such high rates and…
Photoswitchable bioactive compounds: Photoactivation of drugs, enzymes, and other bio-molecules allows for achieving of the spatial and temporal control of their action. We design and synthesize compounds that are inactive in the dark but are converted into bioactive form upon irradiation with light of an appropriate wavelength. One of our…
The Wang Lab studies oxygen activation and C–H/C–C bond functionalization by metalloenzymes.
Molecular oxygen is a powerful oxidant, but its reaction with ground-state singlet molecules is kinetically unfavorable due to its spin-forbidden nature. To harness the oxidizing power of oxygen and manipulate biomolecules, iron-containing…