Ph.D. Vanderbilt University 2014
B.S. University of Florida 2009
Our goal is to better understand the ways in which lipids and small molecules contribute to diseases affecting human health and use this knowledge to develop diagnostic and prognostic tools based on molecular signatures of the disease. To achieve this, the Hines Lab develops and applies bioanalytical methods using ion mobility-mass spectrometry (IM-MS) to enhance the throughput and dimensionality of lipidomics and metabolomics experiments. One focus of the group is antibiotic resistance, where we are characterizing the metabolic alterations in antibiotic resistant pathogens and developing IM-MS methods for antibiotic susceptibility testing and small molecule screening.
Kelly M. Hines and Libin Xu, “Lipidomic consequences of phospholipid synthesis defects in Escherichia coli revealed by HILIC-ion mobility-mass spectrometry,” Chemistry and Physics of Lipids, 2019, 219, 15-22. DOI: 10.1016/j.chemphyslip.2019.01.007
David R. Raleigh, Navdar Sever, Pervinder K. Choksi, Monika Abedin Sigg, Kelly M. Hines, Bonne M. Thompson, Daniel Elnatan, Priyadarshini Jaishankar, Paola Bisignano, Francesc R. Garcia-Gonzalo, Alexis Leigh Krup, Markus Eberl, Eamon F. X. Byrne, Christian Siebold, Sunny Y. Wong, Adam R. Renslo, Michael Grabe, Jeffrey G. McDonald, Libin Xu, Philip A. Beachy, Jeremy F. Reiter, “Cilia-associated oxysterols activate Smoothened,” Molecular Cell, 2018, 72 (2), 316-327. DOI: 10.1016/j.molcel.2018.08.034
Kelly M. Hines, Adam Waalkes, Kelsi Penewit, Elizabeth A. Holmes, Stephen J. Salipante, Brian J. Werth, Libin Xu, “Characterization of the Mechanisms of Daptomycin Resistance among Gram-Positive Bacterial Pathogens by Multidimensional Lipidomics,” mSphere, 2017, 2 (6), e00492-17. DOI: 10.1128/mSphere.00492-17
Kelly M. Hines, Dylan H. Ross, Kimberly L. Davidson, Matthew F. Bush, Libin Xu, “Large-Scale Structural Characterization of Drug and Drug-like Compounds by High-Throughput Ion Mobility-Mass Spectrometry,” Analytical Chemistry, 2017, 89 (17), 9023-9030. DOI: 10.1021/acs.analchem.7b01709.
Kelly M. Hines, Josi Herron, Libin Xu, “Assessment of altered lipid homeostasis by HILIC-ion mobility-mass spectrometry-based lipidomics,” Journal of Lipid Research, 2017, 58, 809-819. DOI: 10.1194/jlr.D074724
Kelly M. Hines, Jody C. May, John A. McLean, Libin Xu, “Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry,” Analytical Chemistry, 2016, 88 (14), 7329-7336. DOI: 10.1021/acs.analchem.6b01728.
Kelly M. Hines, G. Charles Ford, Katherine Klaus, Brian Irving, Beverly Ford, Kenneth Johnson, Ian Lanza, K. Sreekumaran Nair, “Application of high-resolution mass spectrometry to measure low abundance isotope enrichment in individual muscle proteins,” Analytical and Bioanalytical Chemistry, 2015, 407 (14), 4045-4052. DOI: 10.1007/s00216-015-8641-2
Kelly M. Hines, Billy R. Ballard, Dana M. Marshall and John A. McLean, “Structural mass spectrometry of tissue extracts to distinguish cancerous and non-cancerous breast diseases,” Molecular BioSystems, 2014, 10 (11), 2827-3032. DOI: 10.1039/C4MB00250D
Kelly M. Hines, Samir Ashfaq, Jeffrey M. Davidson, Susan R. Opalenik, John P. Wikswo and John A. McLean, “Biomolecular Signatures of Diabetic Wound Healing by Structural Mass Spectrometry,” Analytical Chemistry, 2013, 85 (7), 3651-3659. DOI: 10.1021/ac303594m
For a current list: https://scholar.google.com/citations?user=vA9jfvcAAAAJ