Tags: Organic Seminar


Molecule U Want: Freedom of Choice Reaction Discovery with Malononitrile and Beyond.

Malononitrile is a readily available feedstock chemical distinguished by its high acidity and unusual electronic structure. Guided by a “Freedom of Choice” philosophy in reaction discovery, we are exploring this underutilized reagent as a platform for inventing new, often enantioselective, transformations with the potential to simplify access to sp3-rich drug-like molecules. This lecture will highlight historical milestones in malononitrile…


Research Seminar: Margaret Solecki


Proximity Labeling Technologies
to Illuminate Glycan-Protein Interactions


Ligand-Directed Approaches to Site-Selective Protein Modification

Precision bioconjugation techniques are essential for constructing well-defined protein-based therapeutics such as antibody-drug conjugates (ADCs). Among native amino acids, cysteine is particularly attractive for site-selective modification due to its high nucleophilicity and low natural abundance. However, most proteins contain multiple free cysteines, making it challenging to target specific residues without affecting protein structure or…


Cu-Catalyzed Difluorocarbene Insertion
Towards Site-Selective Ring Expansion


M2e & NA-based Influenza Vaccine Candidates Protect Against Influenza Infection


Targeted Degradation of Indoleamine 2,3-Dioxygenase 1 Using PROTAC Technology

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that catalyzes the first and rate-limiting step in the oxidative metabolism of tryptophan along the kynurenine pathway. Aberrant activation of this pathway is strongly associated with tumor immune suppression. Overexpression of IDO1 in tumor cells and antigen-presenting cells results in local depletion of tryptophan and accumulation of immunomodulatory…


Oxidative Coupling Reactions of Phenols and Azines Via Cationic and Radical Intermediates

The photochemical oxidative coupling of phenols with a range of coupling partners will be described. Even though the reaction likely involves radical intermediates, selectivity can be controlled by selecting coupling partners with different oxidation and nucleophilicity profiles. In addition, the use of donor acceptor complexes permit coupling with partners that have lower oxidation potentials than the phenols. The use of solid photocatalysts…


Interpreting 1H NMR Spectra: What Does Expertise Look Like and How Can We Measure It?


Enantioselective Total Synthesis
of (-)-Novofumigatonin

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