Tags: Organic Seminar


Controlling Reactivity with Light: Photo-Click Macrocyclization and Photochemistry in UV Opaque Environments

Photochemistry offers precise spatiotemporal control over chemical reactivity, enabling selective transformations using light as an external stimulus rather than conventional chemical reagents. In principle, such control could enable targeted drug activation, real-time imaging, and localized release of bioactive molecules while minimizing off-target effects. However, photo-medical methods are currently limited to mostly topical and subcutaneous…


Total Synthesis of (−)-Illisimonin A Enabled by Pattern Recognition and Olefin Transposition


Total Synthesis of Vilmoraconitine


Literature Seminar: Stephanie Procopio


Molecule U Want: Freedom of Choice Reaction Discovery with Malononitrile and Beyond.

Malononitrile is a readily available feedstock chemical distinguished by its high acidity and unusual electronic structure. Guided by a “Freedom of Choice” philosophy in reaction discovery, we are exploring this underutilized reagent as a platform for inventing new, often enantioselective, transformations with the potential to simplify access to sp3-rich drug-like molecules. This lecture will highlight historical milestones in malononitrile…


Research Seminar: Margaret Solecki


Proximity Labeling Technologies
to Illuminate Glycan-Protein Interactions


Ligand-Directed Approaches to Site-Selective Protein Modification

Precision bioconjugation techniques are essential for constructing well-defined protein-based therapeutics such as antibody-drug conjugates (ADCs). Among native amino acids, cysteine is particularly attractive for site-selective modification due to its high nucleophilicity and low natural abundance. However, most proteins contain multiple free cysteines, making it challenging to target specific residues without affecting protein structure or…


Cu-Catalyzed Difluorocarbene Insertion
Towards Site-Selective Ring Expansion


M2e & NA-based Influenza Vaccine Candidates Protect Against Influenza Infection

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