Skip to main content
Skip to main menu Skip to spotlight region Skip to secondary region Skip to UGA region Skip to Tertiary region Skip to Quaternary region Skip to unit footer


A Mechanistic Study of Coproheme Decarboxylase

Shelby Parrott, speaker
Shelby Parrott
Graduate Student, Department of Chemistry
University of Georgia
Chemistry Building, Room 400
Inorganic Seminar

Heme is an essential cofactor required for numerous biological reactions in the vast majority of organisms, and its biosynthesis is a complex process. Three heme biosynthetic pathways have been identified, with the most recent being the coproporphyrin dependent (CPD) pathway. In the CPD pathway, coproporphyrinogen III is oxidized to coproporphyrin, followed by iron insertion into the tetrapyrrole, forming coproheme1. The final step of the CPD pathway is the decarboxylation of coproheme to heme by the enzyme, coproheme decarboxylase (ChdC)2. The CPD pathway is exclusively found in firmicutes and actinobacteria, both of which are pathogenic and highly antibiotic resistant bacteria that contribute to human disease3. The investigation into the mechanism of the penultimate enzyme in the CPD pathway, ChdC, will assist in the development of new antimicrobial compounds.   


  1. Dailey HA, Dailey TA, Gerdes S, Jahn D, Jahn M, O'Brian MR. 2017. Prokaryotic heme biosynthesis: multiple pathways to a common essential product. Micro Molec Bio Rev. 81(1): 1-62.
  2. Dailey HA, Gerdes S, Dailey TA, Burch JS, Phillips JD. 2015. Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not us protoporphyrin. PNAS. 112(7): 2210-2215.
  3. Dailey HA, Gerdes S. 2015. HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in firmicutes and actinobacteria. Arch Biochem Biophys. 574: 27-35.

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: 

Registration and credit

AP Credit, Section Changes, Overrides,

Graduate inquiries:

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Main Email:

Head of Chemistry: Prof. Jason Locklin