Tags: Analytical Seminar


Recently Developed Molecular Weight, Polydispersity and Structure Characterizations of Synthetic Polymers


Generating morphologically and chemically diverse surfaces through post-polymerization modification of polymer brushes

Click chemistry combined with post-polymerization modification (PPM) of reactive polymer brushes can result in a wide array of surfaces, differing in chemical functionalities and morphologies.1 Poly(pentafluorophenyl acrylate) (Poly(PFPA)) brushes react quickly and quantitatively towards primary amines, with few side reactions, and have been shown to be a promising reactive scaffold for use in templating a variety of functionalities and…


Two-Photon-Induced Luminescence of Gold Nanoparticles: Experimental Design and Analysis

In 2000, Mohamed et al. reported gold nanoparticles with a luminescence quantum yield six orders of magnitude greater than bulk gold.1 The enhancement was attributed to localized surface plasmon resonances. Recent studies understand and engineer the luminescence of nanoparticles by the altering particle geometries and plasmon modes.2-4 Interestingly, gold nanoparticles show two-photon-induced luminescence (TPIL) that can be measured at the…


Assisting the Identification of Isomeric N-linked Glycans with Hydrophilic Interaction Liquid Chromatography (HILIC) Retention Models


Innovations in Glycosaminoglycan Mass Spectrometry: Algorithms for Automated Interpretation and Sequence Analysis


From solution to the gas-phase. What can we learn on the structure, dynamics and distribution of biomolecules?

Recent innovations in speed, accuracy and sensitivity have established mass spectrometry (MS) based methods as a key technology for the mapping and analysis of small molecules, lipids, peptides, protein, DNA and DNA-protein complexes in biological systems. In particular, Ion Mobility Spectrometry – Mass Spectrometry provides a powerful tool for the identification of structural motifs, and when complemented with theoretical calculations, it…


Mass Spectrometry, Ion Mobility, and Ion Chemistry: Tools for Characterizing the Structures of Proteins in Solution and in the Gas Phase

 Native mass spectrometry is an emerging approach for characterizing the stoichiometry, assembly, and shapes of protein complexes in solution. Native mass spectrometry is especially useful for investigating proteins and protein complexes that are challenging to characterize using condensed-phase experiments, including those that are heterogeneous, have large mass, and are membrane bound. I will discuss how my lab uses mass spectrometry, ion…


Mechanical and Chemical Recycling of Thermoplastics


Fluorescence Resonance Energy Transfer (FRET)-based activatable probe for biological analysis

In the past, cellular imaging, and biological analyte assays utilize traditional fluorescence-based techniques. However, since most conventional fluorescence-based probes display only modest fluorescent changes, low sensitivity, low specificity, and so on, those methods have been limited by those drawbacks.1 Recently developed FRET-based probes can overcome those limitations largely to detect and monitor molecular targets in live cells in vitro…
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