Skip to main content
Skip to main menu Skip to spotlight region Skip to secondary region Skip to UGA region Skip to Tertiary region Skip to Quaternary region Skip to unit footer


Characterizing HMGA Binding to DNA and Inhibition by Small Molecules

Prof. Karen L. Buchmueller
Furman University
Chemistry Building, Room 400
Organic Seminar

HMGA (High Mobility Group Protein A) proteins are a family of nuclear proteins that bind AT rich DNA. These proteins are crucial during development and certain immune responses; however, their upregulation is linked to the spread of cancer. Unfortunately, the presence of HMGA1 (a subfamily of HMGA) is diagnostic of metastasis and poor prognosis for the patient. Therefore, downregulation of the DNA binding activity may allow for the development of novel therapeutics. However, these proteins are intrinsically disordered and they utilize two or three AT hook motifs to bind DNA in a cooperatively manner, making this family of proteins difficult to target. Our lab is developing a molecular understanding of how to target and disrupt these DNA binding proteins. In addition, we are studying how naturally occurring variations in the consensus AT hook sequence alters motif structure and DNA affinity.

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: 

Registration and credit

AP Credit, Section Changes, Overrides,

Graduate inquiries:

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Main Email:

Head of Chemistry: Prof. Jason Locklin