Skip to main content
Skip to main menu Skip to spotlight region Skip to secondary region Skip to UGA region Skip to Tertiary region Skip to Quaternary region Skip to unit footer


New Strategies in Radical-Based Aliphatic C-H Fluorination

Chemistry Building, Room 400
Organic Seminar


In 2018, almost 50% of all small-molecule drugs approved by the FDA contained fluorine. The appeal of fluorine substitution in drug candidates can be attributed to the improved properties fluorine exerts on a molecule such as blocking undesired metabolism and increasing potency, absorption, or binding affinities. Incorporation of the radio isotope, [18F], to bioactive molecules also has applications in medical imaging as well as pharmacokinetic studies. Though countless methods exist for C-F bond formation, the realm of direct C-H fluorination is rather limited. Previous methods for direct fluorination employ fluorine gas, which is toxic and extremely reactive—requiring specialized handling. Rapid progress has been made in the last decade regarding arene fluorination through directed palladium catalyzed systems utilizing milder fluorinating reagents; however, the direct fluorination of unactivated C-H bonds remains largely underdeveloped. Carbon-centered radical generation has emerged as an effective strategy to fluorinate reactive aliphatic C-H bonds under mild conditions. Recent advances in this field attempt to combat the selectivity and reactivity issues related to aliphatic C-H fluorination under milder systems and expand these strategies to [18F] fluorination.

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: 

Registration and credit

AP Credit, Section Changes, Overrides,

Graduate inquiries:

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Main Email:

Head of Chemistry: Prof. Jason Locklin