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An Analysis of Photo-CORM Di-(2-hydroxynaphtyl)cyclopropenone

Photo of Rohan Bhavsar, speaker
Rohan Bhavsar
Graduate Student, Department of Chemistry
University of Georgia
iSTEM Building 2, Room 1218
Organic Seminar

Carbon monoxide (CO) in the last two decades has garnered an increase in interest for its therapeutic effects when applied at a controlled dosage. Some notable effects include antiinflammation, anti-apoptosis, and anti-oxidation. Recently, the use of a molecular vehicle to deliver CO, known as a CO-releasing molecules (CORMs), has been a widely studied topic for their ability to deliver a controlled dosage of CO.

Presented here is the molecule which is a CORM developed in our lab which releases CO through photolysis, thus classifying this compound as a Photo-CORM. Exposure to light, ideally between the wavelengths of 300 – 420 nm, targets the photochemically unstable cyclopropenone ring which induces the release of CO. The characterization and quantification of DHNCP will be discussed alongside the application and future of the project.

Di-(2-hydroxynaphtyl)cyclopropenone (DHNCP) molecule diagram


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