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Molecular Editing via Nitrogen Deletion: A Strategy for Remodeling Molecules in Organic Synthesis

Portrait of Idris Olukoya, speaker
Idris Olukoya
Graduate Student, Department of Chemistry
University of Georgia
iSTEM Building 2, Room 1218
Organic Seminar

Diagram of molecular editing strategy showing result of nitrogen deletion

Molecular editing has recently gained attention as an emerging strategy to diversify and enable the building of complex molecules, and it directly modifies the core of the molecular skeleton.

Unlike peripheral editing, which involves the editing of the peripheral sites of the molecule, skeletal editing enables the modification of the ring by inserting, deleting, or transposition one atom directly and selectively. [1]

In 2021, three synthetic strategies which can delete the internal nitrogen atom of secondary amines to forge new carbon-carbon bonds were reported by the research group of Levin, Lu, and Antonchick.[2][3][4] This seminar's overview will focus on the latest developments based on the reported strategies in molecular editing via nitrogen deletion for remodeling molecules and their application in organic synthesis.


[1]          Hui, C., Wang, Z., Wang, S., Xu, C. Org. Chem. Front., 2022, 9, 1451-1457

[2]          Kennedy, S. H.; Dherange, B. D.; Berger, K. J. Levin, M. D.  Nature, 2021, 593, 223-227

[3]          Qin, H; Cai, W.; Wang, S.; Guo, T; Li, G.; Lu, H. Angew. Chem. Int. Ed. 2021, 60, 20678-20683

[4]          Chunngai, H.; Lukas, B.; Carsten, S.; Antonchick. A. P.  J. Am. Chem. Soc. 2021, 143, 18864-18870

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