Skip to main content
Skip to main menu Skip to spotlight region Skip to secondary region Skip to UGA region Skip to Tertiary region Skip to Quaternary region Skip to unit footer


7-Dehydrocholesterol Encapsulated Lipid Nanoparticles as a Radiation-activated Radiosensitizer

Portrait of Jianwen Li, speaker
Jianwen Li
Graduate Student, Department of Chemistry
University of Georgia
Science Learning Center, Room 345
Materials Chemistry and Nanoscience Seminar

The pursuit of therapeutics that can be selectively activated by radiation to enhance radiotherapy's efficacy is a pressing need. In this study, we utilized 7-Dehydrocholesterol (7DHC), a biosynthetic precursor of cholesterol, as a lipid targeted radiation-induced radiosensitizer (RIRS) for non-small cell lung cancer (NSCLC). 7DHC, reacting with radiation-induced reactive oxygen species (ROS), initiates a radical chain reaction with polyunsaturated fatty acids (PUFAs) in cell membranes, resulting in direct lipid peroxidation and cell death through ferroptosis. To enhance targeting precision, we incorporated NTSmut, a ligand for NTSR1 overexpressed in various malignancies, into liposomal nanoparticles. Our tests demonstrate that these NTSmut-incorporated and 7DHC-loaded liposomal nanoparticles are minimally toxic yet significantly boost radiation efficacy by activating ferroptosis in cancer cells. This induced ferroptosis, serving as a highly immunogenic cell death (ICD) pathway, further amplifies the cancer immune response. This controlled ferroptosis activation strategy presents a promising therapeutic index, paving the way for potential clinical applications.

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: 

Registration and credit

AP Credit, Section Changes, Overrides,

Graduate inquiries:

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Main Email:

Head of Chemistry: Prof. Jason Locklin