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Recent Advances of Metal Carbenoids: from Diazo Precursors to Safe Carbene Precursor

Portrait of graduate student Wei-Chih Lo, speaker
Wei-Chih Lo
Graduate Student, Department of Chemistry
University of Georgia
iSTEM Building 2, Room 1218
Organic Seminar

Fischer carbene complexes with six valence electrons, characterized by a singlet carbene center, demonstrate an amphiphilic nature.1 The transition metal carbene complexes share similarities with Fischer carbene complexes, potentially functioning as both nucleophiles and electrophiles.2 This duality enables chemists to accomplish intricate transformations, such as C-H bond insertion or cyclopropanation. Despite their utility, the synthetic application of transition metal carbene complexes is often hindered by the preparation methods and stability of their carbene precursors, typically diazo compounds.3 Recent advancements have introduced methods to prepare non-stabilized carbene precursors, facilitating various reactions previously accessible through transition metal carbene complexes.4-6



[1] Nolan, S.P. Coord. Chem. Rev. 2009, 253, 862–892.

[2] Doyle, M. P. Chem. Rev. 2010, 110, 704–724.

[3] Bull, J. A. OPR&D 2020, 24, 67–84.

[4] Nagib, D. A. Science 2022, 377, 649–654.

[5] Nagib, D. A.  Nat. Chem. 2024, 16, 107–113.

[6] Nagib, D. A.  Chem 2024, 10, 1–13.

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