Tags: Analytical Seminar


Advances in Tandem Mass Spectrometry Approaches for the Structural Characterization of Sulfated Glycosaminoglycans

Glycosaminoglycans (GAGs) are complex linear carbohydrates that participate in a broad range of biological processes.1 Their structural analysis is challenging, and there has been considerable research into tandem MS approaches. Electron activation methods such as electron detachment dissociation (EDD) produce glycosidic fragments and an abundance of cross-ring fragmentation, but this approach is confined to FTICR mass spectrometers. EDD has…


Analysis of Heterogeneous and Higher Molecular mass analytes using Charge Detection Mass Spectrometry

Charge Detection Mass Spectrometry (CD-MS), quantifies the charge on an individual ion and, from a velocity measurement of each electrostatically accelerated ion, also determines its mass-to-charge ratio. Together these measurements allow a calculation of the mass for a highly charged ion. CD-MS extends the reach of mass spectrometry into the giga Dalton regime. It also allows the analysis of very heterogeneous samples. Mixtures of high mass…


Developing novel lead compounds for kynurenine-3-monooxygenase inhibition

Kynurenine Monooxygenase (KMO) is a potential drug target for neurodegenerative diseases such as Alzheimer’s disease1-3. In this study, we tested kynurenine analogs and sulfonylureas predicted by a pharmacophore model4 for competitive inhibition of KMO. Given the therapeutic relevance of KMO inhibition, and that obtaining a pure recombinant human KMO is still a challenge, our lab seeks to crystallize Cytophaga hutchinsonii (ch) KMO and hopefully…


Breaking through the diffraction limit: Super Resolution Microscopy as a chemistry tool

Traditionally used in cell biology, super resolution microscopy (SRM) has become a valuable tool for observing chemistry in action. With resolution capabilities down to 10 nm, SRM has succeeded in observing samples below the theoretical limit of light microscopy. The major SRM techniques utilize the chemical potential and photoactivation characteristics of fluorophores as well as deconvolution of raw image data to obtain high resolution images.…


Building Superior Biomolecules: Enhancing ADCs, Replacing ELISA, and Resurrecting ADEPT

Antibodies are important biological scaffolds used in biotherapeutics and diagnostics. The utility of antibodies can be expanded by coupling them with small-molecule drugs or proteins. Using both protein engineering and bioconjugation chemistry, we have created a series of highly-characterized antibody-conjugates that simultaneously deliver multiple drugs to induce new forms of synthetic lethality. Using these platforms, we are able to…


Inherent Electric Fields, Hydration and Ion Pairing at the Air/Water Interface: Ocean and Aerosol Surface

Our oceans are the largest generators of highly saline and organic-rich atmospheric aerosol.  Research in the Allen lab investigates ocean and sea spray aerosol systems to understand interfacial speciation and organization to then inform on atmospheric aerosol, cloud, and marine surface reactivity, correlating to climate change and its contributing uncertainties. Surface selective experiments reveal surface propensity of hydrated ions and…


New Developments in Mass Spectrometry-Based Metabolomics

The highly dynamic nature of metabolites and their abundances makes metabolomics a powerful endpoint of the ‘omics’ cascade, yielding a molecular profile that is closest to the physiological phenotype. Metabolomic profiles are therefore sensitive to subtle perturbations observed in early disease stages or disease progression, which may be difficult to detect at the proteome or transcriptome levels. Human diseases are multi-factorial in nature,…


Differentiating Sugars Stereoisomers with a Simple Mass Spectrometry Method

Mass spectrometry is a powerful analytical technique, but one of the biggest challenges is in differentiating stereoisomers. Techniques such as NMR and X-ray are good at this, but they typically require pure samples and significantly greater amounts of material than mass spectrometry. We have developed a simple mass spectrometry method that can differentiate pentoses and hexoses, and determine the linkage position and anomericity of…


Advances in the Quantitative Detection of Hydrogen Sulfide

Hydrogen sulfide is one of three important gaseous transmitter molecules in mammalian biology. The presence and absence of gasotransmitters have been linked to various processes and disfunctions in the body, from vasodilation to Alzheimer's disease in hydrogen sulfide's case. As a result, there is a substantial push in research to make gasotransmitter-donating systems for biomedical applications. Unfortunately, the use of hydrogen sulfide in…


Electrochemical deposition of chalcogenide semiconductor films: InSe and GeTe

Electrodeposition is a low cost, room temperature method for the deposition of semiconductor thin films. Using Electrochemical Atomic Layer Deposition (EALD) and Potential Pulse Atomic Layer Deposition (PPALD), films with atomic layer control can be achieved. By reducing one monolayer of one element onto the substrate, followed by a molecular layer of a second element, films of varying thicknesses can be made. These films can be used in such…
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